#Canine spectra 10 software
Data processing and analysis were performed with sDECT viewer software package. The post-processing was performed on Workstation AW4.5. The polychromatic images (quality control images) and monochromatic images at 101 continuous energy levels from 40 to 140 keV were reconstructed at a slice thickness of 1.25 mm and a slice interval of 1.25 mm with the data obtained by plain and double-phase contrast-enhanced scan. sDECT, single-source dual-energy spectral CT SMA, superior mesenteric artery. Animals were sacrificed for pathological examinations at 4 and 8 h after embolization ( n = 4 at each time point). sDECT scans were performed at five time points (before embolization, 2, 4, 6 and 8 h after embolization). The experimental protocol is shown in Figure 1. After embolization, the catheter was removed and local compression haemostasis was performed.
Angiography was performed to demonstrate the embolization situation. All the protocols were approved by the Institutional Animal Care and Use Committee and were conducted according to the Institutional guidelines for Care of Laboratory Animals.Ī 5 Fr catheter was delivered to the middle colic artery originating from the SMA trunk by the Seldinger technique, and then the 2.0 × 2.0 × 2.5 mm self-made gelatin sponge particles were injected. This study aims to explore the diagnostic value of sDECT in a SMAE dog model and to evaluate the ischaemic severity using iodine-based images.Įight healthy, adult, hybrid dogs (male or female, weight: 15–22 kg) were provided by our hospital (First Affiliated Hospital of Harbin Medical University). It is of great importance to explore the diagnostic value of sDECT in SMAE. 6, 8 A recent study 9 has investigated the performance of spectral CT in depicting the superior mesenteric artery (SMA). This makes it possible to analyse the iodine uptake of tissues or organs directly and effectively reflect the blood perfusion state of tissues or organs. sDECT allows differentiation of materials and measurement of iodine concentration in the tissues via iodine-based images. 7 This is useful as it improves image quality and the visualization of fine anatomic structures. Monochromatic imaging is less vulnerable to artefacts such as beam hardening and pseudoenhancement. Single-source dual-energy spectral CT imaging (sDECT) is a new functional imaging technique using a dual-energy scan mode. 3– 5 However, conventional single-energy MDCT is more susceptible to X-ray hardening artefacts and cannot separate materials of different densities. MSCTA has become the first choice to evaluate SMAE. Multislice CT angiography (MSCTA) combined with double-phase contrast-enhanced scan not only can determine the position and severity of superior mesenteric artery embolus (SMAE) but also can evaluate the severity and range of ischaemic damage to the mesentery and intestinal wall. Recent great advances in multislice CT (MSCT) have encouraged research into the diagnosis of AMAE. 1 Since the affected site, range and severity varies, AMAE has complex and variable clinical symptoms and signs, laboratory tests and imaging manifestations, and its early diagnosis is very difficult because of overlapping manifestations with primary diseases. Acute mesenteric arterial embolus (AMAE) is a rare but critical surgical acute abdomen, and its hospital mortality is up to 55.5% in spite of gradual improvements in treatment.